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KMID : 0379520190350010065
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한국독성학회지
2019 Volume.35 No. 1 p.65 ~ p.74
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Subchronic and Reproductive/Developmental Toxicity Studies of Tetrahydrocurcumin in Rats
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Majeed Muhammed
Natarajan Sankaran
Pandey Anjali
Bani Sarang
Mundkur Lakshmi
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Abstract
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Tetrahydrocurcumin (THC) is a major metabolite of curcumin, which is obtained from Curcuma longa. THC has various benefits and overcomes the bioavailability issue of curcumin. To establish it as a pharmacologically active molecule, its safety profile has to be determined. Thus, the present study aimed to determine the preclinical safety profile of THC in a 90-day subchronic and reproductive/developmental toxicity study in Wistar rats. THC at oral doses of 100, 200, and 400 mg/kg was administered daily for 90 days. Rats in the recovery group were kept for 14 days after treatment termination. The animals were observed for treatment-related morbidity, mortality, and changes in clinical signs, clinical pathology, and histopathology. In the reproductive/developmental toxicity study, THC at 100, 200, and 400 mg/kg was administered orally to rats and the reproductive/developmental parameters in adult male and female rats and pups were observed. THC at up to 400 mg/kg/day of did not have any significant effect on all parameters in male and female rats in both toxicity studies. Thus, 400 mg/kg/day can be considered as the no-observed-adverse-effect-level of THC in rats.
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KEYWORD
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Tetrahydrocurcumin, Toxicity, Subchronic, Reproductive/developmental
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